Prof. Dr. Horst Domdey

Date of Birth:      29. October 1951                    

Nationality:          German     

Family Status:    married, 2 children

PROFESSIONAL EXPERIENCE

Since 2006          
Managing Director of Bio^M Biotech Cluster Development GmbH, Martinsried, Germany. Bio^M GmbH is a spin-off of Bio^M AG focussing exclusively on cluster development, technology transfer, advisory and location marketing activities.          

Since 1998          
Honorary Professor at the Ludwig-Maximilians University Munich.

Since 1998          
Managing Director (Vorstand) of Bio^M AG Munich Biotech Development, Martinsried, Germany. Creation and establishment of Bio^M as a tech-transfer, advisory and seed capital organ which has played a major role in the successful development of the Munich Biotech Cluster. Successful raising a seed and a venture capital fund.               

1994-1998          
Professor for Biochemistry at the Institute of Biochemistry of the Ludwig Maximilians University Munich. Basic research on the processing of mRNA precursors. Successful development of active and passive vaccines against Pseudomonas aerugi­nosa including preclinical and clinical studies.   
Initiation, execution and supervision of several German and European genome projects. Gene expression analysis of the human heart.         
Successful management of the Munich Biotech Initiative that made Munich one of the three winners of the German BioRegio contest 1996.

1984-1993          
Group leader and research associate at the Gene Center of the Ludwig-Maximilians University Munich. Basic research on the processing of mRNA precursors. Research on active and passive vaccines against Pseudomonas aeruginosa. Development of new methods in DNA sequence analysis

1982-1984          
Postdoctoral fellow at the University of California, San Diego, La Jolla, and at the California Institute of Technology, Pasadena, USA. Research on splicing of mRNA precursors in yeast.

1982                   
Postdoctoral fellow at the Max Planck Institute of Biochemistry, Martinsried, Germany. Research on the replication of viroids.

1980-1982          
Postdoctoral fellow at the Swiss Institute for Experimental Cancer Research (ISREC), Epalinges, Switzerland. Research on the structure and expression of the gene and the mRNA coding for the mouse C3 complement protein.

1979-1980          
Postdoctoral fellow at the Max Planck Institute of Biochemistry, Martinsried, Germany. Research on the structure and function of viroids, tRNAs and rRNAs, and on a new RNA ligase activity detected in wheat germ extracts.

EDUCATION       

1976-1979           
Doctoral thesis at the Max Planck Institute of Biochemistry, Martinsried, and the Ludwig-Maximilians University, Munich: Determination and analysis of the complete structure of the plant pathogen viroid RNA

1970-1975          
Studies in chemistry and biology at the Friedrich-Alexander University Erlangen, Germany. Final exam ("Staatsexamen", MS-equivalent) passed with honours.

LANGUAGES

German (native), English (fluently), French (good knowledge)

FURTHER ACTIVITIES

1988-1990          
Member of several committees for the European Human Genome Analysis Program

1988-1995          
Technology Advisor of the Protestant Church of Bavaria

since 1993          
Member of the Board of Directors of the German Society for the Promotion of Biomedical Research

1994                     
Cofounder of MediGene AG

1998-2008          
Management of 2 life science Incubators (17,000 m²) in Martinsried and Freising-Weihenstephan.

since 2001          
Member of the Committee for Industry and Research of the Association of the German Chambers of Industry and Commerce

2002-2003          
Chairman of the International Life Science Forum e.V.

since 2003          
Chairman of the Bavarian Genome Research Network ("BayGene")

2004-2006          
Chairman of the Steering Committee of the German BioRegionsSince

2004          
Member of the Board of Directors of BIO Deutschland

since 2004          
Member of the Steering Committee of the Council of the European BioRegions CEBR

since 2006          
Member of the Plenum of the Munich Chamber of Industry and Commercesince

2009          
Member of the Biotechnology Initiative of the Secretary General of the United Nations

AWARDS

Research fellowship from the "Studienstiftung des Deutschen Volkes"  (1977-1979)

Research fellowship from the "Deutsche Forschungsgemeinschaft" (German Research Foundation) (1981-1982)

Research fellowship from the European Molecular Biology Organization (1983)

SELECTED SCIENTIFIC PUBLICATIONS (10 out of 108)

• 1. Gross, H.J., Domdey, H., Lossow, C., Jank, P., Raba, M., Alberty, H. and Sänger, H.L. (1978). Nucleotide sequence and secondary structure of Potato Spindle Tuber Viroid. Nature 273, 203-208.
• 2. Konarska, M., Filipowicz, W., Domdey, H. and Gross, H.J. (1981). Formation of a 2'-phosphomonoester, 3', 5'-phosphodiester linkage by a novel RNA ligase in wheat germ. Nature 293, 112-116.
• 3. Domdey, H., Wiebauer, K., Kazmaier, M., Müller, V., Odink, K. and Fey, G. (1982). Characterization of the mRNA and cloned cDNA specifying the third component of mouse complement. Proc. Natl. Acad. Sci. USA 79, 7619-7623.
• 4. Domdey, H., Apostol, B., Lin, R.-J., Brody, E. and Abelson, J. (1984). Lariat structures are in vivo intermediates in yeast pre-mRNA splicing. Cell 39, 611-621.
• 5. Ng, R., Domdey, H., Larson, G., Rossi, J.J. and Abelson, J. (1985). A test for intron function in the yeast actin gene. Nature 314, 183-184.
• 6. Köhrer, K., Vogel, K. and Domdey, H. (1990). A yeast tRNA-precursor containing a pre-mRNA intron is spliced via the pre-mRNA splicing mechanism. EMBO J. 9, 705-709.
• 7. zu Putlitz, J., Kubasek, W.L., Duchêne, M., Marget, M., von Specht, B.-U. and Domdey, H. (1990). Antibody production in Baculovirus-infected insect cells. BioTechnology 8, 651-654.
• 8. Dujon, B., ..., Domdey, H., et al. (1994). Complete DNA sequence of yeast chromosome XI. Nature 369, 371-378.
• 9. Specht, B.-U., Knapp, B. , Muth, G., Bröker, M., Hungerer, K.-D., Diehl, K.-D., Massarrat, K., Seemann, A. and Domdey, H. (1995). Protection of immunocompromised mice against lethal infection with Pseudomonas aeruginosa by active or passive immunization with recombinant P. aeruginosa outer membrane protein F and outer membrane protein I fusion proteins. Infect. Immun. 63, 1855-62.
• 10. Stumpf, G. and Domdey, H. (1996). Dependence of yeast pre-mRNA 3'-end processing on CTF1: a sequence homolog of the mammalian AAUAAA-binding factor. Science, 274, 1517-1520.